|
KMID : 0043320130360040423
|
|
Archives of Pharmacal Research
2013 Volume.36 No. 4 p.423 ~ p.429
|
|
|
A new phenanthrene derivative and two diarylheptanoids from the roots of Brassica rapa ssp. campestris inhibit the growth of cancer cell lines and LDL-oxidation
|
|
Wu Qian
Cho Jin-Gyeong
Yoo Ki-Hyun
Jeong Tae-Sook
Park Ji-Hae
Kim Su-Yeon
Kang Ji-Hyun
Chung In-Sik
Choi Myung-Sook
Lee Kyung-Tae
Chung Hae-Gon
Bang Myun-Ho
Baek Nam-In
|
|
|
Abstract
|
|
|
|
Brassica rapa ssp. campestris (Brassicaceae) is a conical, deep purple, edible root vegetable commonly known as a turnip. We initiated phytochemical and pharmacological studies to search for biological active compounds from the roots of B. rapa ssp. campestris. We isolated a novel phenanthrene derivative, 6-methoxy-1-[10-methoxy-7-(3-methylbut-2-enyl)phenanthren-3-yl]undecane-2,4-dione, named brassicaphenanthrene A (3) along with two known diarylheptanoid compounds, 6-paradol (1) and trans-6-shogaol (2), through the repeated silica gel (SiO2), octadecyl silica gel, and Sephadex LH-20 column chromatography. The chemical structures of the compounds were determined by spectroscopic data analyses including nuclear magnetic resonance, mass spectrometry, ultraviolet spectroscopy, and infra-red spectroscopy. All compounds exhibited high inhibitory activity against the growth of human cancer lines, HCT-116, MCF-7, and HeLa, with IC50 values ranging from 15.0 to 35.0 μM and against LDL-oxidation with IC50 values ranging from 2.9 to 7.1 μM.
|
|
|
KEYWORD
|
|
|
Brassica rapa ssp. campestris, Brassicaphenanthrene A, 6-Paradol, trans-6-Shogaol, HCT-116, HeLa, Low density lipoprotein, MCF-7
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|
|